CACTUS: INTEGRATING CLONAL ARCHITECTURE WITH GENOMIC CLUSTERING AND TRANSCRIPTOME PROFILING OF SINGLE TUMOR CELLS

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity.Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.The confidence of the cell-to-clone mapping can b

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White paper from a CTSA workshop series on special and underserved populations: Enhancing investigator readiness to conduct research involving LGBT populations

Despite head total joy 2023 the significant health disparities experienced by lesbian, gay, bisexual, and transgender (LGBT) populations, few investigators affiliated with the National Institutes of Health-funded Clinical and Translational Science Award Programs are conducting research related to this underserved population.We provide recommendatio

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